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Hyaluronic acid filler is considered temporary, and 2 year follow-up and 1 year MRI imaging shows a dramatic decrease in remaining implantable filler

All the reaction mixtures were incubated at rt for 4 h

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Advancing FDA-approved excipients with enzymatically cleavable coatings, innovating adaptable charge-reversal mechanisms responsive to heterogeneous tumour microenvironments, and exploring alternative activation modalities beyond photoresponsive systems will accelerate clinical translation and broaden applications beyond oncology to include retinal therapy, inflammatory diseases, and mRNA vaccine delivery, heralding a new era of personalized, multimodal, and highly effective therapies driven by the next generation of charge-reversible nanocarriers