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Histopathological findings revealed a significant decrease in the testicular volume, length and diameter of the seminiferous tubules, germinal epithelium height, motility, and viability in the MSG group compared to the control and sham groups, which were consistent with the findings of other reports [54, 56, 57]

In the attempt to shed light on the mechanism underlying heart failure in RTT, we investigated the contribution of the carnitine cycle to the onset of mitochondrial dysfunction in RTT cardiac tissue using an in vivo mouse model