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Description Research Overview GHK is an endogenous tripeptide that forms a stable high-affinity complex with Cu(II), yielding GHK-Cu, a well-characterized ligand-metal pair.[1,2] In research settings, GHK-Cu serves as a model for copper delivery and signaling, enabling investigation of matrix protein synthesis, metalloproteinase regulation, antioxidant responses, and transcriptional reprogramming under standardized conditions.[3,4] Its versatility has made it a reference tool in dermatologic, regenerative, and oxidative stress research

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