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The mechanism of action of N-acetylcysteine (NAC): The emerging role of H(2)S and sulfane sulfur species

ABBREVIATIONS 6-MP 6-mercaptopurine 6-TG 6-thioguanine (6-mercaptopurine and 6-thioguanine) CAO 4-[N-(S-cysteinylacetyl)amino]phenylarsonous acid cAVTP cis-6-(2-acetylvinylthio)-purine CPIC p-chlorophenyl isocyanate DMAC dimethylarsino-cysteine DMACG dimethylarsino-cysteinylglycine EGFR epidermal growth factor receptor GSH glutathione GCAO 4-[N-(S-cysteinylglycylacetyl) amino] phenylarsonous acid GT gamma-glutamyl transferase GSAO [4-(N-(S-glutathionylacetyl) amino)phenylarsonous acid] GS-cAVTP glutathione s-cis-6-(2-acetylvinylthio)-purine Glu glutamate Gly glycine GS-tAVTG glutathione s-trans-6-(2-acetylvinylthio)-guanine PENAO 4-(N-(S-penicillaminylacetyl)-amino)phenylarsonous acid SCPG S-(N-pchlorophenylcarbamoyl) glutathione tAVTG trans-6-(2-acetylvinylthio)-guanine

SOD and Glutathione work in sequence to tackle the strongest oxidants in the body, the superoxide radical oxygen molecules

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