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Recent studies have shown that epigenetic marks, comprising chemical modifications of DNA and histones, are associated with FXN gene silencing

PLoS ONE 8:e66639 Kim JH, Jin S, Eo H, Oh MS, Lim Y (2023) Two faces of catechol-O-methyltransferase inhibitor on one-carbon metabolism in Parkinsons disease: a meta-analysis

Moreover, in the hypothyroid animals, many of the mast cells showed partial or complete degranulation, which was in contrast to the non-activated mast cells in the animals with normal thyroid function.[ref] Other animal studies show that hypothyroidism increases mast cell infiltration into the liver and mast cell levels in the bone marrow

This approach would capitalize both on our understanding of circadian pathophysiological pathways in asthma, and existing redox-targeted therapeutics, whilst minimizing off-target effects associated with hormone based therapies such as melatonin