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N Engl J Med (2012) 366(4):34859

An important component of -glucans in Pleurotus sajor-caju helps to protect from oxidative stress and obesity in obese mice by the action mechanism of bioactive components, which involves in inhibition of adipocytes and lipolysis

Two common problems stand out

Challenges in the therapy of NeuroHIV As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of HIV-1 provirus in both T-cell reservoirs and non-CD4 T-cell reservoirs, there is a critical need to develop new brain-penetrating agents that can effectively target both CNS and peripheral immune cells to simultaneously silence HIV-1 and reduce the risk of neuroinflammation