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Other risk factors contributing to the highly vulnerable state of OPCs and (developing) oligodendrocytes are high levels of mitochondrial oxygen consumption, in addition to a greater need than other cells to acquire and retain iron (required for differentiation as well as myelination) [154]

La deficiencia de G6PD se produce por diversos mecanismos genticos como deleciones, mutaciones puntuales y sustituciones que afectan la transcripcin, procesamiento o estructura primaria de la enzima, lo que funcionalmente lleva a una disminucin de la actividad enzimtica o prdida de afinidad por el sustrato

Emerging evidence suggests that gut ecological dysregulation has an impact on clinical HF and its subtypes (e.g., HF with a preserved ejection fraction) (151)

Once reconstituted, it should be refrigerated and used within 30 days for best results