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TCDD induced hepatic inflammation by accelerating arachidonic acids metabolism to up-regulate cyclooxygenase and lipoxygenases activity to produce leukotrienes, leading to steatohepatitis (Doskey et al

This is corroborated by a retrospective study by Rennebaum et al., where PSC in 41 PSC-only patients showed accelerated disease progression compared to 115 IBD-PSC patients, and PSC-only patients had a higher risk of developing cirrhosis [204]

References Koletzko B, Baker S, Cleghorn G, et al (2005)