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To make it relatable, think of PE-22-28 like a highlight reel of galaninstripped down to the part of the peptide most responsible for desired outcomes like stress regulation and neuroprotection, without carrying all of galanins extra baggage. Pietri Frontiers In Pharmacology How PE-22-28 Works (Mechanism of Action) PE-22-28 works by mimicking a key fragment of the larger galanin neuropeptide, allowing it to interact with the same receptor systems in the brain and nervous system