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In MDD, this peripheral-central coupling is likely amplified by BBB dysfunction characterized by increased permeability, neurovascular inflammation, and associations with symptom severity [172, 173] thereby lowering the threshold at which peripheral KP activation translates into central glutamatergic, oxidative, and neuroimmune dysregulation

Neuron 85(6):11931199 Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W et al (2017) A review of sleep disorders and melatonin

10.1038/s42003-021-02825-4 85 GemmaC.VilaJ.BachstetterA.BickfordP

You might also notice that your mood, energy, and skin begin to improve as inflammation reduces and the microbiome starts to rebalance