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The list below reflects how the published rodent studies were set up and what is known about NNMT in human biology

An orally available NNMT inhibitor if the animal bioavailability data translates to humans would have significant practical advantages

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Research published in Biochemical Pharmacology demonstrated that treating cells with 5-Amino-1MQ effectively blocks this leak. It inhibits NNMT, forcing Nicotinamide back into the salvage pathway