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We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig

In addition, DMB significantly attenuated but did not completely eliminate pulmonary artery AS induced by an 8-week exposure to intermittent hypoxia and hypercapnia (IHC) in ApoE / mice and Ldlr / mice (Xue et al., 2017)