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When symptoms are attributed to high B12 intake, they typically include: Skin reactions : Acne-like eruptions or rosacea-type rashes, particularly with hydroxocobalamin injections (listed as rare adverse effects in the product information) Gastrointestinal disturbances : Mild nausea, diarrhoea, or abdominal discomfort Headaches : Occasional reports of headache following B12 injections Anxiety or restlessness : Anecdotal reports, though causation remains unestablished It is crucial to distinguish between symptoms caused by elevated B12 levels and those arising from the underlying conditions that elevate B12

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Moreover, a nuclear magnetic resonance (NMR) study showed that N-terminal FUS-LCD (FUS-LCD-N) forms a fibril core via hydrophilic interactions 64,65