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This cyclical pathway is vital to maintain energy homeostasis 1,2,4

doi: 10.1016/j.neulet.2006.11.031 159 OrdonezL

for example, in salt-sensitive hypertension, capsaicin modulates the AMPK/Akt/Nrf2 pathway to coordinately reduce oxidative stress and inflammatory cytokine expression, conferring organ protection (33, 106)