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Phase II study of daratumumab (DARA) monotherapy in patients with 3 lines of prior therapy or double refractory multiple myeloma (RRMM): 54767414MM2002 (Sirius)

This can disrupt the delicate hormonal signals from the brain (hypothalamus and pituitary gland) to the ovaries, leading to a halt in ovulation and, consequently, missed periods (a condition called hypothalamic amenorrhea)