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The exclusion of patients with COPD and asthma in key daratumumab studies and the incidence of bronchial hyperreactivity AEs seen in early trials resulted in the recommendation for post-administration prophylaxis with bronchodilators and inhaled corticosteroids in patients with a history of COPD [13, 65]

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While little is known on the sex differences in MTHFR polymorphisms, sex hormones, such as estrogen is known to play a protective effect in female patients with schizophrenia as for the impact of neurodevelopment and social maturation 55

Molecular analysis of jejunal, ileal, caecal and recto-sigmoidal human colonic microbiota using 16S rRNA gene libraries and terminal restriction fragment length polymorphism