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Its formulation is generally used to: Help improve skin radiance and surface glow Reduce the appearance of dullness and uneven skin tone Support mild pigmentation concerns when used consistently Provide gentle cleansing suitable for daily use In clinical practice, such whitening bars are best considered as adjunct skincare, not standalone treatment for melasma or deep pigmentation

[18] [19] Long-term use of proton pump inhibitors or H2-receptor antagonists can also impair B12 absorption

Evidence from colitis models demonstrates that GLUT1 ablation preferentially dampens Th17 cell expansion, while largely preserving the regulatory capacity of Treg cells (66), underscoring the potential for precise immunometabolic targeting

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