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Kucharzewska P, Maracle CX, Jeucken KCM, et al

A very fast ion-pair reversed-phase HPLC method for the separation of the most significant nucleotides and their degradation products in human red blood cells

Next, we found that CXCL10 directly bound to IL18R1 to impair ovarian function through three pathways: inducing ovarian fibrosis through p-JNKp-JUN COL1A1, promoting primordial follicle overactivation through p-AKTp-FOXO3A, and increasing ovarian inflammation through p-P65 IFN