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Identifying ways to activate adiponectin/AdipoR signaling is expected to pave the way for the development of definitive therapies for the metabolic syndrome, type 2 diabetes, and atherosclerosis

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The Guideline also noticed these issues and stated: " To avoid unnecessary risks for patients and others, placebo controlled studies should be performed in a highly controlled setting, with stringent follow-up to apply predefined escape criteria, rescue medication and stopping rules " 1