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Nat Rev Clin Oncol (2020) 17:50415

Cell Mol Life Sci 70:17531761 Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV (2013) Relationship between cyclophilin A levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein E4 carriers and blood-brain barrier breakdown

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On the other hand, it cannot be excluded that the transient downregulation of TTR mRNA, encoding protein transthyretin, might negatively affect hippocampal IGF1R expression (Vieira et al., 2015), as it is known to act synergistically with IGF-1 on IGF1R activation (Vieira et al., 2016)