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Flavonol glycosides are hydrolysed by microbial -glucosidases to the corresponding aglycones which are then biotransformed by intestinal microbiota through mostly oxidative C-ring cleavage and demethylation, or dehydroxylation reactions to yield simple phenols and benzoates, see Fig

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Keeping a good level of selenium might be harder than it looks

CHAC1 inhibition via CRSPR/Cas9 mediated knock-in of an enzyme inactivating mutation demonstrates a novel strategy to preserve muscle glutathione levels under wasting conditions but fails to prevent muscle wasting in mice