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J Lipid Res 72.12152778 2021 PMC8566900 Schur E, Carnell S

Ten patients with GBM were included in this study

However, ferroptosis resistance mechanisms including iron sequestration, lipid repair enzymes, and antioxidant systems such as cystine transporters (xCT) and glutathione peroxidase 4 (GPX4) restrict the full therapeutic potential of ferroptosis inducers, necessitating a comprehensive strategy to overcome these adaptive barriers [6, 7]

The result is a discrete pulse of GH release subject to normal somatostatin-mediated negative feedback, theoretically preserving pulsatility, unlike exogenous recombinant GH which produces sustained non-physiologic serum levels