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Abstract Hyperpigmentation constitutes a significant dermatological challenge, exacerbated by oxidative stress and glycation

It is important to note that mood state is commonly assessed by self-rating scales, such as self-administered questionnaires, which are not objective measurements (101)

CAN is characterized by damage to the nerve fibers that innervate the heart and blood vessels, leading to reduced heart rate variability (variability in the time interval between heartbeats) and increased risk of mortality (80)

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