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13 C 6 -Glucose tracing metabolomics Cells were cultured in glucose-free RPMI-1640 (Teknova) media supplemented with 2 g/L 13 C 6 -glucose (Sigma) and 10% dialyzed serum (Life Technologies, A3382001)

The impaired DNA repair and resulting oxidative stress in patients suffering from COPD explain a higher prevalence of lung cancer compared to smokers without airway obstruction (Adcock et al