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Yet, follicular B cells remain immunologically competent even when GPX4 is absent

GSH Concentration = Total Glutathione Concentration - [GSSG Concentration] x 2 *One molecule of GSSG (oxidized glutathione) is equivalent to two molecules of GSH (reduced glutathione)

NAD + levels are limiting in this reaction and determine the efficiency of mitochondrial energy production 15

2 This result was demonstrated for the primary efficacy variable (change in pain intensity after 4 hours) and for multiple secondary efficacy variables, including pain relief, pain intensity reduction, response, sustained response, relief of associated symptoms, use of rescue medication, disability relief, and global assessments of effectiveness