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some research indicates that greater doses (200 g/day) result in more noticeable decreases in TSH levels and antibody titers [32,37], whereas lower doses (83100 g/day) have only mild or no effects

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Always consult with your healthcare provider before starting any new supplement, especially if you have genetic mutations like MTHFR or COMT, or if you are taking medications that may interact with B12 absorption