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The TCA cycle is initiated by citrate synthase (CS) which catalyses the condensation of oxaloacetate, produced after the completion of a round of TCA, and acetyl-CoA, the common end product of all substrate oxidation pathways, including the pyruvate dehydrogenase complex, fatty acid -oxidation (FAO), the degradation of ketone bodies, and BCAA

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Let it sit until the solution is fully clear

They have leveraged mRNA and lipid nanoparticles (LNP) to produce their new experimental vaccine, which uses OspA, the same immunogen in previous protein-based formulations