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Interestingly, however, the ratios between E2 and its metabolites were not significantly affected by COC use, even though 17-estradiol levels were also significantly reduced in COC users

8B) in the VPA-ASD group included a significant enrichment of Desulfovibrionaceae and a depletion of beneficial families such as Muribaculaceae and Lactobacillaceae

Do you see what we mean when we say that human data is limited

Simultaneously, it upregulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), enabling coordinated tissue remodeling rather than simple collagen deposition