kinetic study on the reactions of platinum drugs with glutathione

kinetic study on the reactions of platinum drugs with glutathione Influence chemical structure and mechanism of hydrolysis pharmacological activity and toxicological profile of approved The Next Generation of Platinum

Name: kinetic study on the reactions of platinum drugs with glutathione Influence chemical structure and mechanism of hydrolysis pharmacological activity and toxicological profile of approved The Next Generation of Platinum
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The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs Chemical Reviews kinetic study on the reactions of platinum drugs with glutathione Schematic representation A: Mode of action of platinum based drug Recent Advances of PlatinumBased Anticancer Frontiers Glutathione responsive and exhausting metal nanomedicines for robust synergistic cancer therapy Combination strategies of platinum based drugs (cisplatin or Download Scientific Diagram

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However, under the stimulation of other signals such as oxidative stress, Nrf2 is activated after separation from Keap1 to activate Nrf2-targeted antioxidant genes, it includes heme oxygenase 1 (HO-1), NAD(P)H, GCL, SOD, CAT, GR, GPx, GST, and maintains the oxidative/antioxidant balance in cells by up-regulating their expression (Venugopal and Jaiswal, 1998)

doi: 10.1007/s00360-013-0776-x

So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest