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Metformin inhibits gluconeogenesis, decreases hepatic glucose output, and increases insulin sensitivity

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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12

It is also beneficial for individuals who have difficulty absorbing nutrients due to dietary or medical conditions