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Figure 2 4.1 Key molecular pathways related to neuroinflammation-mediated ferroptosis 4.1.1 Cyclic GMP-AMP synthase/stimulator of interferon genes The stimulator of interferon genes (STING) pathway is activated by double-stranded DNA (dsDNA), which activates the expression of interferon (IFN) via interferon regulatory factor 3 (IRF3) (Liu et al., 2015)