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British Journal of Nutrition, 88 (S2), S165S176

73 Dilp8/INSL3 derived from tumor tissue activates the Lgr3 receptor in the hypothalamus, which increases the expression of anorexigenic nucleobinding 1 and decreases the expression of the orexigenic neuropeptides short neuropeptide F (sNPF) and NPF, triggering cachexia-associated anorexia