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Dan C, Chi J, Wang L (2015) Molecular mechanisms of the progression of myelodysplastic syndrome to secondary acute myeloid leukaemia and implication for therapy

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Notably, the GDF15 deficiency persisted after treatment with oral contraceptives, a standard PCOS management approach, but was ameliorated with combined therapy of spironolactone, pioglitazone, and Met (SPIOMET), which increased GDF15 levels (78)

Heterogeneity and plasticity Intratumoral heterogeneity in phenotypic features, including molecular (gene and protein expression), structural (cellular morphology), and functional (metabolism) characteristics, is a defining feature of various cancers