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In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]

Although promising outcomes have been achieved in preclinical studies in alleviating fibrosis intensity in various tissues and models, the complexity of the ECS defines its limitations