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The distance fluctuation (DF) parameter for each pair of residues i and j in a protein system is defined as D ij = ( d ij d ij ) 2 , where d ij is the time-dependent distance between the C atoms of residues i and j , and the brackets indicates the time-averaged distance over the entire trajectory

V.Cavalcanti-AdamE

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Preclinical studies have observed its modulatory effects on corticotropin and somatostatin secretion, suggesting its role in neuropeptide feedback loops relevant to stress adaptation and hormonal rhythms