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Biochemical Properties and Catalytic Activities of Ser-GSTs GSTs are versatile enzymes, accommodating diverse substrates/ligands in the active site or L-sites (Table 2), and catalyzing diverse enzymatic reactions as a function of the active site signature (Chronopoulou et al., 2017a)

Additionally, CuSAE also exhibits peroxidase (POD)- and glutathione oxidase (GSHOx)-mimicking activities, which elevate oxidative stress in tumor cells, thereby blocking the compensatory repair mechanisms and continuously activating tumor disulfidptosis

Fourth, although the current study included nearly 4,000 patients, many treatments still have fewer than 100 responses, which limits the reliability of the estimates of treatment outcomes

Cell 50 , 504515 (2013)