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DSF inhibits proteasome activation (Voorhees and Orlowski, 2006), leading to the accumulation of misfolded proteins and potentially toxic protein aggregates ( 8.4 Downregulation of PLK1 expression Polo-like kinase 1 (PLK1), which is highly expressed in tumor cells, is a key serine/threonine kinase involved in many important cell cycle functions such as mitotic entry, centrosome maturation, cell cycle progression, and cytoplasmic division (Triscott et al., 2012)

Curcumin in combination with other adjunct therapies for brain tumor treatment: existing knowledge and blueprint for future research

Gannon, M

Piglets: 2 ml intramuscular, 3 days after birth