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Similarly, the minimum abundance of Akkermansia or Bifidobacterium needed to exert antidepressant effects has not been defined, which limits the development of targeted microbiota interventions

Studies have shown that these systems effectively maintain therapeutic drug levels in the eye, enhancing treatment adherence and reducing the incidence of ocular surface disease associated with conventional therapies (243, 244)

This complex symptomatology reflects the widespread and multisystem nature of PD pathology, which extends far beyond the basal ganglia to involve cortical, limbic, and peripheral autonomic structures [3, 4]