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MIL-101 (Fe)@RSL3 NPs deliver iron ions and RSL3 to ccRCC cells, which generate large amounts of ROS through Fenton reactions, leading to the accumulation of LOX, and as GPX4 activity is inhibited by RSL3, this combination induces cell death by ferroptosis (171)

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It can also reduce the expression of phosphatidylinositol 3-kinase (PI3K), threonine kinase (AKT), p-threonine kinase (p-AKT), glycogen synthase kinase-3 (GSK-3), and p-GSK-3