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Comprehensive molecular and immune profiling of non-small cell lung cancer and matched distant metastases suggests distinct molecular mechanisms underlying metastasis

For cALD patients, the only treatment to date is allogeneic bone marrow transplantation, which is associated with a high morbidity and mortality and is available only to nearly asymptomatic X-ALD children

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The clinical utility of conventional copper chelators is limited by dose-dependent toxicities, primarily stemming from systemic copper deficiency and off-target chelation of essential metals, such as zinc and iron