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46,47 Furthermore, compared to people without depression, patients with MDD have been demonstrated to have a shorter life expectancy

Metabolic processes produce energy and anabolic growth substrates to sustain cell survival and proliferation

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In addition, sustained DAMP-mediated signalling can sustain NF- and inflammasome activation, sustaining elevated levels of inflammatory cytokines at all times because of elevated levels of basal inflammatory cytokines and their release even in the absence of any initiating cause, effectively relating pulmonary inflammation with systemic effects [35]