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Diabetic retinopathy-an underdiagnosed and undertreated inflammatory, neuro-vascular complication of diabetes

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Known risk factors for methotrexate toxicity include dosing errors, metabolic syndrome, hypoalbuminemia, renal dysfunction, lack of folate supplementation, and the concomitant use of drugs that interfere with methotrexate metabolism

These findings guide clinical practice while highlighting research priorities to fully establish NACs therapeutic potential in respiratory medicine