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GSH deficiency or a decrease in the GSH/glu-tathione disulfide ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in diseases, such as cancer, Parkinson's disease, and Alzheimer's disease

DOHH from PCBP-depleted cells also exhibits loss of the iron cofactor when the cells are exposed to mild iron deficiency

M.DazA.IturrinoL.et al

Other approaches that may be helpful include Qigong, yoga , acupuncture , massage and healing touch , mindfulness-based stress reduction , cognitive behavioral therapy , and other forms of stress-relieving or psychosocial support (Chien 2013