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In addition, E3 ligase Pirh2 ubiquitinates HuR protein and facilitates its degradation in response to heat stress, controlling cell survival under elevated temperatures (Daks et al

However, while some studies suggest that people with MTHFR mutations might be more vulnerable to these toxins, this remains an area of active research and should be interpreted cautiously

In addition to the reduced matrix effect, the elution of the retained matrix components can be switched to waste resulting in less contamination of the MS