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Building on these findings, future studies will focus on in vivo pharmacokinetic and pharmacodynamic profiling to validate EV-QuerCars antioxidant and anti-aging efficacy in preclinical models, including biodistribution, sustained release kinetics, and systemic toxicity assessments

The Mantel test is based on the estimation of the correlation between two matrices summarizing the results from pathway analysis

Nevertheless, further validation in larger clinical cohorts is required before such an approach can be broadly implemented

Furthermore, texture grading avoids possible confounding by sun-induced pigmentation