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Therefore, high GSH/GSSG ratios in cancer cells can also be explained by increased flux through the pentose phosphate pathway (PPP), which produces NADPH (Li et al., 2014a

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The third is the secretion of bioactive factors, which may influence local and systemic physiological processes (Wilkinson et al., 2020)

For example, in the peroxisome where verylongchain FAs are preferentially metabolized, carnitine shuttles the fatty acyl end products of beta oxidation between the peroxisome and the mitochondria (Steiber et al., 2004)