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The absence of approval reflects the absence of a demonstrated favorable benefitrisk balance in the indications studied, not an untested promise waiting to be fulfilled

Moreover, grafting fetal astrocytes bearing SOD1G93A to the spinal cord of healthy mice precipitated ALS-like pathology 244 , while transplanting healthy astrocytes slowed ALS progression in rats carrying mutant SOD1 G93A (ref

Difficult questions sometimes take a long time to answer." (Emphasis added.) We are a long way from having such a validated clinical scoring system In a May 2017 article, Dr

Capitalizing on the druggable nature of the ubiquitin system, significant progress has been made, particularly with proteolysis-targeting chimeras (PROTACs), which demonstrate compelling radiosensitizing effects [14, 15]