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Prognostic Factors for Well-Differentiated Thyroid Cancer Age appears to be the single most important prognostic factor.[11] The prognosis for differentiated carcinoma (papillary or follicular) without extracapsular extension or vascular invasion is better for patients younger than 40 years.[11-15] Patients considered at low risk according to age, metastases, extent, and size risk criteria include women younger than 50 years and men younger than 40 years without evidence of distant metastases

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