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Since Dihexa (HGF pathway) and Semax (BDNF pathway) target independent neurotrophic systems, researchers hypothesize that combining them could produce additive or synergistic effects on synaptic density and cognitive performance

An alternative approach escalates both agents simultaneously but at slower intervals, extending the total escalation period to twenty weeks or longer

Sikiric et al., 2020b), additionally acting as membrane stabilizer (Park et al., 2020), with particular reference to ulcerative colitis (Sikiric et al., 2011)