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doi: 10.1371/journal.pone.0290813 162 MengN.LiuQ.DongQ.GuJ.YangY

The resulting stressful environment attracts macrophages that trigger local inflammation in the islet

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Introduction Methamphetamine (MA), a central nervous system (CNS) stimulant, is the third most used recreational drug world-wide ( The notion that MA might damage the human brain is derived primarily from preclinical animal data showing that high doses of MA, or its related stimulant amphetamine, cause loss of brain dopamine neuronal markers ( Although the precise mechanism(s) by which high doses of MA cause brain damage in preclinical studies remain uncertain, excessive oxidative stress is a likely candidate